By KYW medical editor Dr. Brian McDonough
PHILADELPHIA (CBS) — There’s new information in the battle against ALS, or Lou Gehrig’s disease, in the journal Nature and Neuroscience.READ MORE: Woman Beaten To Death With Pipe Inside Old City Office Building, Police Say
It has to do with a mutation in the TBK 1 gene associated with as many as 10% of cases world-wide. According to the researchers, TBK 1 encodes for a protein involved in inflammation and the clearing of debris in cells.
It interacts with two other genes, OPTN and SQSTM1. All these different genes are involved in the same cellular process, and the theory is that if they can try to attack one, they can attack all of them.READ MORE: Suspect Arrested After Holding Teen Girl Hostage During Barricade In Overbrook, Police Say
The genes interact in the clearing of what is called cellular debris in the body. The cellular debris and inflammation that goes along with it can impact cells and muscles in the body, and the neurodegenerative changes that might be related to this.
This is all being done at the genetic level. It will take time, but it’s exciting research.MORE NEWS: PennDOT Dealing With Twin Challenges As Latest Winter Storm Bears Down On Philadelphia Region