Rain freezing on contact has caused accidents all around the region and closures of highways like Interstate 95, the Blue Route and I-76.
Two separate accidents are causing major traffic issues during the Friday morning commute.
Police responded to the scene and shut down the left lane of I-95N, making room for tow trucks and equipment to address the accident.
Officials say the closures begin at 8 p.m. with a single lane, then at 10 p.m. two lanes will be closed and by 11 p.m. all lanes will be shut down. They will reopen each day at 5 a.m.
AAA Mid-Atlantic estimates about 100 million people will travel at least 50 miles.
An accident this morning is causing trouble for commuters.
Two accidents on I-95 Wednesday morning are tying up traffic and delaying the morning rush even further for drivers.
PennDOT press secretary Rich Kirkpatrick said Wednesday that anyone considering driving long distances on the highway should try to postpone their travel.
New Jersey lawmakers passed a pair of measures stemming from the politically motivated lane closures near the George Washington Bridge last year.
An overturned vehicle is causing a major backup on the Ben Franklin Bridge, westbound into the city.
The fire broke out around 9 a.m. on Thursday near 4th and Race Streets after construction crews reportedly struck a gas main.
The DRPA also says four lanes to Pennsylvania will be open during morning rush hours and four lanes to New Jersey will be open for the afternoon rush hour.
Investigators say one person was killed in a crash that backed-up traffic for several hours on the Schuylkill Expressway early Thursday morning.
Northbound I-95 has reopened after a truck fire had forced all of the lanes in that direction to close at Woodhaven Road in Northeast Philadelphia.
Officials say there will be no weight or truck restrictions and all three lanes will be open.