Police detectives said they were questioning the girls, whom they believe are responsible for at least three assaults along North 17th Street in North Philadelphia, just off the Temple campus.
Temple University officials were sounding the alarm after several students were targeted in a series of off-campus attacks.
Officials say five small fire were intentionally set on floors inside what will be the residential tower of Morgan Hall, at Broad Street and Cecil B. Moore Avenue in North Philadelphia.
The Temple Board of Trustees has announced a tuition freeze for the 2012-2013 school year.
Thursday was a big day for thousands of Temple University students — and a big day for the school.
The unidentified male student is being treated at Temple University Hospital.