The 76ers (15-35) have lost four straight and 14 of their last 17 games. They also have lost six in a row at home for the first time since the 1996-97 season.
Carter-Williams led Philadelphia with 21 points and Elliot Williams had 18 off the bench.
The Detroit Pistons’ frontcourt overwhelmed the short-handed Sixers for a 113-96 victory Saturday night.
Thaddeus Young scored 29 points, Michael Carter-Williams added 17 and Elliot Williams had 15 for the Sixers, who have dropped 11 of their last 13 home games, including five straight.
Evan Turner sank a layup at the buzzer to give the Philadelphia 76ers a 95-94 win over the Boston Celtics in a matchup of the two worst teams in the Atlantic Division on Wednesday night.
The Sixers have lost 10 of 12.
Kevin Durant had a triple double to lead the OKC Thunder past the Sixers 103-91 Saturday night.
Kyle Lowry had 18 points, 13 assists and 10 rebounds, and DeMar DeRozan scored 34 points to help the Toronto Raptors beat the Philadelphia 76ers 104-95 on Friday night.
Evan Turner scored a career-high 34 points and grabbed 11 rebounds, leading the Philadelphia 76ers to a 110-106 victory over New York on Wednesday night that snapped a three-game skid and sent the Knicks to a fifth straight loss.
Michael Carter-Williams led Philadelphia, which has lost seven of eight, with 31. Thaddeus Young had 18. Spencer Hawes had 11 points and tied his season high with 14 rebounds.
The Sixers were never really in this one as they were dominated by the Chicago Bulls 103-78 Saturday night.
Back in October, the Sixers made their first 11 shots and raced to leads of 19-0 and 26-4, putting the champs on their heels a night after they received their rings.
Young hit the final big shot in a fourth quarter loaded with back-and-forth baskets, a contested jumper from the left of the arc off a feed from Michael-Carter Williams.
Spencer Hawes and James Anderson each had 17 points to lead the Sixers, losers of four in a row.
Thaddeus Young scored 22 points for the Sixers, who have lost three straight after reeling off four consecutive road wins.