Arthritis In The Hands And WristsIf you know someone with gnarled and misshapen hands, chances are you know someone suffering from arthritis. Fortunately, not everyone will get arthritis in the hands and wrists. Family history is a factor according to Dr. Eon Shin, an Orthopedic Surgeon at St. Mary Medical Center. Another factor is how you use your hands and wrists on a day-to-day basis. People who regularly perform repetitive strenuous activities such as in construction may be predisposed to the condition.